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Comments for one in ten thousand
https://walkerma.wordpress.com
A medicinal chemist searching for that needle in a haystackMon, 08 Jun 2009 17:33:54 +0000
hourly
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Comment on Word of the week…Racemate by nearlynothingbutnovels
https://walkerma.wordpress.com/2007/03/29/word-of-the-weekracemate/#comment-9351
Mon, 08 Jun 2009 17:33:54 +0000https://walkerma.wordpress.com/2007/03/29/word-of-the-weekracemate/#comment-9351I just stopped back to have a look at this page. The post and discussion are fascinating. One thing that confuses me, though, is the issue of density vs. solubility. How (or why) are these supposed to be related? What am I missing?
Here is the reference I mentioned above:
A new route to chiral bis-tertiary phosphine ligands: synthesis, resolution, and crystal structure of trans-bis-1,2-(diphenylphosphino)cyclopentane and the nickel adduct [trans-1,2-(PPh2)2C5H8]NiBr2. Allen, David L. et al. Journal of the Chemical Society, Chemical Communications (1983), (16), 895-6. CODEN: JCCCAT ISSN: 0022-4936. Journal written in English. CAN 100:34631 AN 1984:34631 CAPLUS
Abstract
Grignard reaction of PhMgBr with diphosphinocyclopentane I (R = Cl), prepd. by heating white P, PCl3 and cyclopentene at 200, gave I (R = Ph) (II). II with NiBr2 in 95% aq. EtOH gave the II.NiBr2 complex (III). Crystn. of III from CH2Cl2 gave crystals of (+)- and (-)-III.CH2Cl2, which were sepd. by hand picking. Treatment of (+)-III.CH2Cl2 with NaCN gave (-)-II. (-)-II with [RhLCl]2 (L = 1,4-cyclooctadiene) catalyzed the hydrogenation of methyl(N-benzoyl)- and (N-benzoyl)dehydrophenylalanine to give hydrogenated products of .apprx.100% optical purity. The crystal structures of II and III.CH2Cl2 are reported.
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Comment on Seprated at birth by Kevin
https://walkerma.wordpress.com/2007/09/01/seprated-at-birth/#comment-9326
Wed, 24 Sep 2008 23:45:44 +0000https://walkerma.wordpress.com/2007/09/01/seprated-at-birth/#comment-9326Excellent… Smithers the resemblance is amazing and funny
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Comment on For Medicinal Purposes… by resistless
https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9320
Wed, 28 May 2008 17:12:32 +0000https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9320resistless says : I absolutely agree with this !
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Comment on For Medicinal Purposes… by pmgb
https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9317
Sat, 26 Apr 2008 06:07:13 +0000https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9317I will show this to my wife (she hates beer and I love it)..
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Comment on August 15, 2007 by Roller Coaster Fan
https://walkerma.wordpress.com/2007/08/15/august-15-2007/#comment-9314
Mon, 21 Apr 2008 19:28:44 +0000https://walkerma.wordpress.com/2007/08/15/august-15-2007/#comment-9314Oh please, you don’t want to ban my favorite pasttime. What next?? smoking?
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Comment on For Medicinal Purposes… by hipster doofus
https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9303
Thu, 13 Mar 2008 14:12:47 +0000https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9303That’s what I’m talking about.
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Comment on by gaussling
https://walkerma.wordpress.com/2007/12/09/136/#comment-9298
Thu, 28 Feb 2008 20:22:01 +0000https://walkerma.wordpress.com/2007/12/09/136/#comment-9298I guess I’m going to have to find the paper to get the background. This is very interesting- thanks for posting on it.
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Comment on For Medicinal Purposes… by mitchandre
https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9213
Fri, 11 Jan 2008 07:02:03 +0000https://walkerma.wordpress.com/2008/01/01/for-medicinal-purposes/#comment-9213Nice find!
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Comment on Separated at birth… by First time commenter
https://walkerma.wordpress.com/2007/12/16/separated-at-birth-4/#comment-8613
Sun, 16 Dec 2007 22:19:36 +0000https://walkerma.wordpress.com/2007/12/16/separated-at-birth-4/#comment-8613Awesome! Best likeness yet.
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Comment on Seprated at birth by hipster doofus
https://walkerma.wordpress.com/2007/09/01/seprated-at-birth/#comment-7701
Fri, 16 Nov 2007 23:30:47 +0000https://walkerma.wordpress.com/2007/09/01/seprated-at-birth/#comment-7701Congratulations on your promotion. Well deserved and not easy to come by at your level.
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