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SIDER 4.1 : Side Effect Resource
Please note that we have no funding to further develop SIDER. The data in SIDER is from 2015 and therefore out of date! However, as of late 2025, we have the good news that the EBI is going to start working (in 2026) on a new database with a similar aim.
SIDER contains information on marketed medicines and their recorded adverse drug reactions. The information is extracted from public documents and package inserts. The available information include side effect frequency, drug and side effect classifications as well as links to further information, for example drug–target relations.
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Database statistics
| Number of drugs and side effects | |||||
| # of SE | # of drugs | # of drug-SE pairs | Pairs with frequency information | ||
|---|---|---|---|---|---|
| 5868 | 1430 | 139756 | 39.9% | ||
| Number of drug–side effect pairs in different frequency ranges | |||||
| frequent (with exact data) | infrequent (with exact data) | rare (with exact data) | postmarketing | total | |
| drug | 24562 (23601) | 16765 (11426) | 11784 (6013) | 19265 | 55730 |
| placebo | 7133 (7133) | 3294 (3294) | 2512 (2512) | 0 | 10748 |
| Version Information | |||||
| The current version (SIDER 4.1) has been released on October 21, 2015. This release uses the MedDRA dictionary (version 16.1) and provides access to preferred terms and lower-level terms. Compared to SIDER 2, the number of drugs has increased from 996 to 1430. Additional side effects have been retrieved by better processing of the labels. Side effects that are mentioned on the label as either potential or not occurring are removed. Data from previous versions of SIDER are available via FTP. | |||||
License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License. For commercial use or customized versions, please contact biobyte solutions GmbH.
Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.