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Disclose all data in publications | Nature
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After thousands of hours of investigation, three clinical trials at Duke University in Durham, North Carolina, were suspended in late 2009 because of the irreproducibility of the genomic 'signatures' used to select cancer therapies for patients. Journals have a duty to help the community by maintaining reproducibility as a cornerstone of the scientific process.
The independent reanalysis of these signatures took so long because the information accompanying the associated publications was incomplete. Unfortunately, this is common: for example, a survey of 18 published microarray gene-expression analyses found that the results of only two were exactly reproducible (J. P. Ioannidis et al . Nature Genet. 41 , 149–155; 2009). Inadequate information meant that 10 could not be reproduced.
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Author information Authors and Affiliations The University of Texas MD Anderson Cancer Center, USA
Keith Baggerly
Corresponding author Correspondence to
Keith Baggerly .
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Comments
Commenting on this article is now closed.
Keith Baggerly 23 September 2010, 19:53
A full list of 47 signators is available at https://groups.google.com/gr...
Zhongyu Hou 25 September 2010, 03:32
Perhaps, the proposal should also be considered by other communities of science.
Keith Baggerly
A full list of 47 signators is available at https://groups.google.com/gr...
Zhongyu Hou
Perhaps, the proposal should also be considered by other communities of science.