Catalyzing Transformative Innovations in Health & Healthcare

The mission of the Duke Institute for Health Innovation (DIHI) is to catalyze transformative innovations in health and healthcare, and to help cultivate a community of innovation and entrepreneurship across Duke University and the health enterprise.

Annual Request for Applications

In alignment with the its mission, the Duke Institute for Health Innovation is constantly seeking out innovations in care delivery. The annual request for applications (RFA) is a mechanism for designing and implementing innovations to address actual and important problems encountered by care providers, patients and their loved ones, and represent urgent health challenges nationally. The RFA is open to all faculty, staff, students, and trainees across Duke University and Duke University Health System.

Applications for the next emerging ideas and innovation funding cycle is now open and closes November 7, 2025. Priority will be given to ideas that harness the power of AI to proactively solve critical healthcare challenges, improving operational efficiency and transforming patient care.

RFA 2026 “office hours” are hosted Wednesdays at 2:30 – 3:00 and Thursdays at 1:30 – 2:30.

DIHI 2026 RFA Timeline
Oct 6, 2025 DIHI RFA open for submission
Nov 7, 2025 11:59 PM Application due date
Feb 2026 Finalists – Presentation to leadership
Apr 2027 Funding start
Nov 2026 Midpoint reporting

Our Focus

Innovation Science & Implementation

Positively impacting clinical care in the real world by putting innovations into practice.

Technology & Innovation Infrastructure

Increasing the speed to deliver value and expanding the potential for achievable innovation.

Workforce Training & Education

Expanding the capabilities of the individuals that make innovation possible.

Featured Projects

From the Blog

How We Innovate: By the Book

At our institute, we don’t just talk about innovation—we live it. Theories and strategies from some of the greatest thinkers on disruption and discovery guide our work daily. Below, we highlight key quotes from The Innovator’s Dilemma and The Idea Factory, showing how we intentionally follow their advice. Compiled and

Read More »

‘Model Facts’ v2 label for HTI-1 compliance

Our team at the Duke Institute for Health Innovation published the first AI product label in healthcare in March 2020 in Nature Digital Medicine. The manuscript describing the ‘Model Facts’ label and the initial example are available here. The first Model Facts label was for the Sepsis Watch model. The publication

Read More »