Lu Chen Associate Professor X-LANCE Lab, School of Computer Science, Shanghai Jiao Tong University Shanghai Innovation Institution (SII) Email: chenlusz [AT] sjtu [DOT] edu [DOT] cn Address: 800 Dongchuan Road, Shanghai 200240, China

Large Language Models (LLM) Group @SJTU X-LANCE Lab

Research Interests

• Natural Language Processing: Dialogue Systems, Large Language Models
• AI for Science: AI for Materials Science, AI for Life Science

Teaching

• Natural Language Processing for CS&AI undergraduates at SJTU, 2021/2022/2023/2024 Fall
• Knowledge Representation and Reasoning for AI undergraduates at SJTU, 2022/2023/2024 Spring

Selected Publication [Google Scholar]

Pre-Training, Alignment, Inference for Large Language Models

• Task-Specific Data Selection for Instruction Tuning via Monosemantic Neuronal Activations
  Da Ma, Gonghu Shang, Zhi Chen, Libo Qin, Yijie Luo, Hongshen Xu, Lei Pan, Shuai Fan, Lu Chen, Kai Yu
  NeurIPS 2025 [Paper]

• Heads up! Large Language Models Can Perform Tasks Without Your Instruction via Selective Attention Head Masking
  Senyu Han, Hongchuan Zeng, Kai Yu, Lu Chen
  ICML 2025 [Paper]

• Reducing Tool Hallucination via Reliability Alignment
  Hongshen Xu, Zichen Zhu, Lei Pan, Zihan Wang, Su Zhu, Da Ma, Ruisheng Cao, Lu Chen, Kai Yu
  ICML 2025 [Paper]

• Evolving Subnetwork Training for Large Language Models
  Hanqi Li, Lu Chen, Da Ma, Zijian Wu, Su Zhu, Kai Yu
  ICML 2024 [Paper]

Autonomous Agents with Large Language Models

• NeuSym-RAG: Hybrid Neural Symbolic Retrieval with Multiview Structuring for PDF Question Answering
  Ruisheng Cao, Hanchong Zhang, Tiancheng Huang, Zhangyi Kang, Yuxin Zhang, Liangtai Sun, Hanqi Li, Yuxun Miao, Shuai Fan, Lu Chen, Kai Yu
  ACL 2025 [Paper][Code]

• MobA: Multifaceted Memory-Enhanced Adaptive Planning for Efficient Mobile Task Automation
  Zichen Zhu, Hao Tang, Yansi Li, Dingye Liu, Hongshen Xu, Kunyao Lan, Danyang Zhang, Yixuan Jiang, Hao Zhou, Chenrun Wang, Situo Zhang, Liangtai Sun, Yixiao Wang, Yuheng Sun, Lu Chen, Kai Yu
  NAACL 2025 (Demo Track) [Paper][Code]

• IBSEN: Director-Actor Agent Collaboration for Controllable and Interactive Drama Script Generation
  Senyu Han, Lu Chen, Li-Min Lin, Zhengshan Xu, Kai Yu
  ACL 2024 [Paper][Website]

• Large Language Models Are Semi-Parametric Reinforcement Learning Agent
  Danyang Zhang, Lu Chen, Situo Zhang, Hongshen Xu, Zihan Zhao, Kai Yu
  NeurIPS 2023 [Paper] [Code]

Large Language Models for Science

• MS-BART: Unified Modeling of Mass Spectra and Molecules for Structure Elucidation
  Yang Han, Pengyu Wang, Kai Yu, Xin Chen, Lu Chen
  NeurIPS 2025 [Paper]

• Developing ChemDFM as A Large Language Foundation Model for Chemistry
  Zihan Zhao^*, Da Ma^*, Lu Chen, Liangtai Sun, Zihao Li, Yi Xia, Bo Chen, Hongshen Xu, Zichen Zhu, Su Zhu, Shuai Fan, Guodong Shen, Kai Yu, Xin Chen
  Cell Reports Physical Science, 2025. [Paper][Code][HuggingFace][央视新闻联播]

• ChemDFM-X: Towards Large Multimodal Model for Chemistry
  Zihan Zhao^*, Bo Chen^*, Jingpiao Li, Lu Chen, Liyang Wen, Pengyu Wang, Zichen Zhu, Danyang Zhang, Ziping Wan, Yansi Li, Zhongyang Dai, Xin Chen, Kai Yu
  Science China Information Sciences, 2024. [Paper][Code][HuggingFace]

• SciEval: A Multi-Level Large Language Model Evaluation Benchmark for Scientific Research
  Liangtai Sun, Yang Han, Zihan Zhao, Da Ma, Zhennan Shen, Baocai Chen, Lu Chen, Kai Yu
  AAAI 2024 [Paper][Website]

Professional Services

Action Editor/Area Chair

• ACL Rolling Review (ARR)

Programme Committee Member

• ACL(Main/Demo Track), NAACL(Main/Demo Track), EMNLP, AAAI, NeurIPS, ICML

Journal Reviewer

• Nature
• Transactions of the Association for Computational Linguistics (TACL)
• IEEE/ACM Transactions on Audio, Speech and Language Processing (TASLP)

Honors and Awards

• 2022 NCMMSC Best Paper Award
• 2021 CCF Outstanding Doctoral Dissertation Award Nomination (17 for CS major in China)
• 2021 ACM (Shanghai Chapter) Outstanding Doctoral Dissertation Award (3 in Shanghai)
• 2020 Shanghai Jiao Tong University (SJTU) Outstanding Doctoral Dissertation Award (15 in SJTU)
• 2018 COLING Area Chair Favorites

Last updated on 2025-05. Visitor number: