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Essays and notes on brain preservation
Essays and notes on brain preservation
About
Metrics
- Towards a more accurate definition of death
- The brain is all you need
- Engram cartography
- Biomolecules: the building blocks of engrams
- Connectomes: the circuitry of engrams
- Engram archaeology: inference in damaged brains
- The materials science of materialism
- Assessing brain preservation quality
- Agonal factors during the dying process
- Notes on the postmortem interval: time is brain
Methods
Publications
- “Glutaraldehyde: A review of its fixative effects on nucleic acids, proteins, lipids, and carbohydrates”, McKenzie 2019
- “Perfusion fixation in brain banking: a systematic review”, McFadden et al. 2019
- “Ex situ perfusion fixation for brain banking: a technical report”, McKenzie et al. 2022
- “Postmortem changes in brain cell structure: a review”, Krassner et al. 2023
- “Fluid preservation in brain banking: a review”, McKenzie et al. 2024
- “Developing an inclusive and transparent structural brain preservation program”, McKenzie and Sparks, 2024
- “Structural brain preservation: a potential bridge to future medical technologies”, McKenzie et al. 2024
- “Biostasis: a roadmap for research in preservation and potential revival of humans”, McKenzie et al. 2024
- “Cryopreservation of brain cell structure: a review”, McKenzie et al. 2024
- “Preservation of cellular structure via immersion fixation in brain banking”, Garrood et al. 2025
- “The right to immediate preservation: addressing legal barriers due to death investigation”, McKenzie et al. 2025
- “What are memories made of? A survey of neuroscientists on the structural basis of long-term memory”, Zeleznikow-Johnston et al. 2025
- “Evaluating ultrastructural preservation quality in banked brain tissue”, Garrood et al. 2025
- “Practitioner forecasts of technological progress in biostasis”, McKenzie et al. 2025
- “Mechanical perfusion in brain banking: methods of assessment and relationship to the postmortem interval”, Garrood et al. 2025
Effective altruism forum posts
Blog posts
- What should we be measuring in brain preservation?
- Can we freeze time?
- Searching for memory in the preserved brain
- That time when a bunch of people all agreed to preserve each other’s brains
- Removing the brain from the skull in brain banking: much more than you wanted to know
- Two paths toward improved structural preservation in brain banking
- Four approaches for long-term fixation-based brain banking
- What would it mean to decode a non-trivial memory from a map of the brain?
- Why wasn’t preservation with the goal of potential future revival started earlier in history?
- How likely is brain preservation to work?
- It would really be fantastic if medical examiners would stop preventing people from accessing high-quality brain preservation
External Links
- ACX 2021 Biostasis/Cryonics Survey
- Apex Neuroscience
- Aspirational Neuroscience Prize
- Ben Best’s Cryonics Website
- Biostasis.com
- Brain Preservation Foundation
- Change.org: Petition for brain preservation rights
- Chemopreservation Wiki
- Hayworth-Miller 2019 Twitter debate about brain preservation
- John Smart’s “Brain Preservation: Why Bother? Getting to the Zen of Life”
- Mike Darwin’s Blog
- Ralph Merkle’s Cryonics Website
- Interviews with Michael Graziano, Rafal Smigrodzki, Shawn Mikula, Peter Gouras, Kennita Watson, Bob Blum, and Adam Marblestone
Note
- All content I created for this site is licensed as public domain (CC-0).