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NeurIPS 2025 Workshop

Biosecurity Safeguards for Generative AI

Upper Level Room 27AB, San Diego Convention Center, USA

🎖️ Awards

Best Paper: $3,000

Runner-up: $1,000

🏆 Best Papers

Without Safeguards, AI-Biology Integration Risks Creating Future Pandemics

Dianzhuo Wang · Marian Huot · Zechen Zhang · Kaiyi Jiang · Eugene Shakhnovich · Kevin Esvelt

GeneBreaker: Jailbreak Attacks against DNA Language Models with Pathogenicity Guidance

Zaixi Zhang · Zhenghong Zhou · Ruofan Jin · Le Cong · Mengdi Wang

🥈 Runner-ups

Deep Ignorance: Filtering Pretraining Data Builds Tamper-Resistant Safeguards into Open-Weight LLMs

Kyle O'Brien · Stephen Casper · Quentin Anthony · Tomek Korbak · Robert Kirk · Xander Davies · Ishan Mishra · Geoffrey Irving · Yarin Gal · Stella Biderman

ABC-Bench: An Agentic Bio-Capabilities Benchmark for Biosecurity

Andrew Liu · Samira Nedungadi · Bryce Cai · Alex Kleinman · Harmon Bhasin · Seth Donoughe

SafeGenie: Erasing Dangerous Concepts from Biological Diffusion Models

Arjun Banerjee · Ethan Tam · Camille Dang · David Martinez

Resisting RL Elicitation of Biosecurity Capabilities: Reasoning Models Exploration Hacking on WMDP

Joschka Braun · Yeonwoo Jang · Damon Falck · Roland S. Zimmermann · David Lindner · Scott Emmons

Important Dates

Paper Submission Deadline (OpenReview)

September 10, 2025 AOE

Author Notification:

October 15, 2025

Camera-Ready Deadline:

October 23, 2025

Workshop:

6 December 2025, 9 a.m. PST — 5 p.m. PST

Workshop Overview

AI & the Bio-Revolution: Innovating Responsibly, Securing Our Future

Generative AI is driving a revolution in biotechnology, but with immense potential comes critical biosecurity challenges.

🚀 The Promise

GenAI offers unprecedented speed in drug discovery, protein engineering, and synthetic biology.

⚠️ The Peril

These same tools could be misused to design novel pathogens and toxins, amplifying dual-use risks at an alarming pace.

🔍 The Gap

AI biosecurity is dangerously underexplored, and most generative tools lack built-in safeguards.

🎯 Our Mission

This workshop will unite experts in AI, synthetic biology, biosecurity policy, and ethics to forge actionable solutions. We will move to embed robust, AI-native safeguards directly within the core of these powerful tools.

🤝 Join us to:

• Engineer next-generation technical guardrails and defenses.
• Establish benchmarks for risk prediction and red-teaming.
• Build a global coalition for secure and responsible AI innovation in the life sciences.