You can configure HTTP Switchboard in such a way as to make it behaves close to how typical ad blockers work.

Here is how the matrix would look like:

I created a backup file which can be restored (from the About tab) in order to make HTTPSB behave close to how ad blockers work (well better in my opinion given the lists of blocked hosts used in that setup):

https://raw.githubusercontent.com/gorhill/httpswitchboard/master/stuff/httpsb-just-block-ads-setup.txt.

From this point, you can head to the Ubiquitous rules tab in the dashboard and select more third-party lists to enhance privacy, etc. The preset lists enabled with this setup are:

• https://raw.githubusercontent.com/gorhill/httpswitchboard/master/assets/thirdparties/pgl.yoyo.org/as/serverlist
• https://raw.githubusercontent.com/gorhill/httpswitchboard/master/assets/thirdparties/hosts-file.net/ad-servers
• https://raw.githubusercontent.com/gorhill/httpswitchboard/master/assets/thirdparties/someonewhocares.org/hosts/hosts
• https://raw.githubusercontent.com/gorhill/httpswitchboard/master/assets/thirdparties/easylist-downloads.adblockplus.org/easylist.txt

Remember: Restoring data from a full backup file will overwrite all your settings!