var destObject = sourceObject.Adapt<Destination>();

sourceObject.Adapt(destObject);

using (MyDbContext context = new MyDbContext())
{
    // Build a Select Expression from DTO
    var destinations = context.Sources.ProjectToType<Destination>().ToList();
    // Versus creating by hand:
    var destinations = context.Sources.Select(c => new Destination {
        Id = p.Id,
        Name = p.Name,
        Surname = p.Surname,
        ....
    })
    .ToList();
}